HuagongsheHuagongshe Chemistry Print Report · For research reference only
Bromoform → Dimethyl 2-bromo-2-methylmalonate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Bromoform | HCID 5558 | — |
| Reactant | Dimethyl methylmalonate | HCID 69104 | — |
| Catalyst | Tetrabutylammonium Fluoride Trihydrate | HCID 11726816 | — |
| Solvent | Carbon Tetrachloride | HCID 5943 | — |
| Product | Dimethyl 2-bromo-2-methylmalonate | HCID 12681741 | 89.4% |
Reaction Steps
Bromoform (1.01 g, 0.4 mol), 1.46 g dimethyl methylmalonate, 200 mg tetra-n-butylammonium fluoride trihydrate (0.632 mmol), and 5 mL carbon tetrachloride were mixed at 24° C. for 2 h. The solution was found to contain 2.01 g (89% yield) of dimethyl α-bromo-α-methylmalonate.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05132475 |
| Source dataset | uspto-grants-1992_07 |
| ORD ID | ord-4bb6ff8b07b0433d905537e877b442f6 |
| Source note | uspto-grants-1992_07 |