Potassium Hydroxide → HCID 21684200, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of diethyl 2-(3-methoxy-5-(methylthio)-4-propoxyphenyl)-2,5-dicyano-5-(3,4,5-trimethoxyphenyl)-1,6-hexanedioate (12.0 g, 0.019 mol) in ethanol (250 ml) was added potassium hydroxide (4.4 g, 0.079 mol). The reaction was heated to 95° C. for 20 minutes, then filtered, and the filtrate concentrated. Methanol (300 ml) was added to the residue, and the solution was stirred at room temperature overnight. The reaction was filtered and the precipitate dried to yield 2-(3-methoxy-5-methylthio)-4-propoxyphenyl)-5-(3,4,5-trimethoxyphenyl)-1,6-hexanedinitrile in a 66% yield. (m.p. 131°-132.5° C.). NMR (CDCl3): δ 1.04 (t, 3H, term CH3), 1.80 (m, 2H, OCH2CH2CH3), 2.18 (m, 2H, CH2 from ##STR30## 2.44 (m+s, SCH3 --CH2 from ##STR31## 3.90 (m, 14H, --OCH3 +OCH2CH2CH3), 6.64+6.72 (s, 2H, ArH), 6.71, 6.77, 6.81, 6.83 (d,d, 2H, ArH).

Provenance & Evidence