反应详情

With stirring, 14.4 g (100 mmol) of ethyl 5-oxopentanoate, 9.2 g (112.6 mmol) of dimethylammonium chloride and 10.8 ml (117 mmol) of 37% formaldehyde solution are heated to 100° C. The mixture is cooled and extracted with 3×30 ml of diethyl ether. The batch is cooled and the organic phases are combined, washed with a saturated solution of sodium chloride, dried over magnesium sulfate and evaporated to dryness, giving ethyl 4-formylpent-4-enoate as a colorless oil which can be further reacted without additional purification.

1. temperatureThe mixture is cooled
2. extractionextracted with 3×30 ml of diethyl ether
3. temperatureThe batch is cooled
4. washwashed with a saturated solution of sodium chloride
5. dry with materialdried over magnesium sulfate
6. customevaporated to dryness