diethyl E-2-amino-4-phosphonomethyl-hept-3-ene-1,7-dicarboxylate → E-2-amino-4-phosphonomethyl-hept-3-ene-1,7-dicarboxylic acid

Participants

Reaction Steps

1.3 g (4:0 mmol) of diethyl E-2-amino-4-phosphonomethyl-hept-3-ene-1,7-dicarboxylate are heated in 15 ml of water for 23 hours to reflux. The reaction mixture is concentrated to 7 ml and the residue is stirred in an ice bath. The precipitated product is isolated by filtration, affording E-2-amino-4-phosphonomethyl-hept-3-ene-1,7-dicarboxylic acid of m.p. 192° C. (dec.).

Provenance & Evidence