Benzyl Alcohol → dibenzyl E-2-amino-4-phosphonomethyl-hept-3-ene-1,7-dicarboxylate

Participants

Reaction Steps

To 3.25 g (10 mmol) of diethyl E-2-amino-4-phosphonomethyl-hept-3-ene-1,7-dicarboxylate and 10.8 g (100 mmol) of benzyl alcohol are added 10 ml of methylene chloride and 20 ml of 4N ethereal hydrochloric acid, and the mixture is allowed to stand for 1 week. The mixture is then evaporated to dryness, and the residue is dissolved in 25 ml of ethanol. To this solution is then added dropwise a solution of 15 ml of propylene oxide in 15 ml of ethanol. The readily volatile constituents are removed by evaporation under reduced pressure, affording dibenzyl E-2-amino-4-phosphonomethyl-hept-3-ene-1,7-dicarboxylate.

Provenance & Evidence