反应详情

10.8 g of 80 to 85% m-chloroperbenzoic acid was added to a dichloromethane (130 ml) solution of 10 g of 1-(t-butyldimethylsilyl)oxymethyl-4-methoxymethoxy-5-methyl-3-naphthalenecarbaldehyde and heated for 1 hour under reflux. The reaction solution was washed with a sodium thiosulfate aqueous solution, after which it was further washed with water, a saturated sodium hydrogencarbonate aqueous solution and a saturated saline solution in this order and dried with anhydrous magnesium sulfate, followed by removal of the solvent by distillation. 9.3 g of the resultant brown oily substance and 2.1 g of sodium hydride were suspended in 21 ml of methanol and 21 ml of water and refluxed for 15 minutes. After cooling, the suspension was rendered acidic by means of dilute hydrochloric acid, followed by extraction with ethyl acetate. After washing with a saturated saline solution, the extract was dried with anhydrous magnesium sulfate, from which the solvent was distilled off. 5 ml of methyl iodide was added to an N,N-dimethylformamide (100 ml) solution of 8.5 g of the resultant brown oily substance and 22.1 g of potassium carbonate, followed by reaction at 60° to 70° C. for 1 hour. The insoluble matters were removed by filtration and the resultant filtrate was diluted with ether. After washing with water, the diluted filtrate was washed with a saturated saline solution and dried with magnesium sulfate. After removal of the solvent by distillation, the residue was purified by silica gel column chromatography (5% ethyl acetate/hexane) to obtain 7.3 g of the captioned compound as a brown oily substance.

1. temperatureheated for 1 hour
2. temperatureunder reflux
3. washThe reaction solution was washed with a sodium thiosulfate aqueous solution
4. washafter which it was further washed with water
5. dry with materiala saturated sodium hydrogencarbonate aqueous solution and a saturated saline solution in this order and dried with anhydrous magnesium sulfate
6. customfollowed by removal of the solvent by distillation
7. temperature21 ml of water and refluxed for 15 minutes
8. temperatureAfter cooling
9. extractionfollowed by extraction with ethyl acetate
10. washAfter washing with a saturated saline solution
11. dry with materialthe extract was dried with anhydrous magnesium sulfate, from which the solvent
12. distillationwas distilled off
13. addition5 ml of methyl iodide was added to an N,N-dimethylformamide (100 ml) solution of 8.5 g of the resultant brown oily substance and 22.1 g of potassium carbonate
14. customfollowed by reaction at 60° to 70° C. for 1 hour
15. customThe insoluble matters were removed by filtration
16. additionthe resultant filtrate was diluted with ether
17. washAfter washing with water
18. washthe diluted filtrate was washed with a saturated saline solution
19. dry with materialdried with magnesium sulfate
20. customAfter removal of the solvent
21. distillationby distillation
22. customthe residue was purified by silica gel column chromatography (5% ethyl acetate/hexane)