Water → HCID 14986466, compound

HRID 654698Notes

Reaction equation

HRID 654698 reaction equation
[CH:1]([C:4]1[CH:5]=[C:6]([CH:16]=[O:17])[C:7]2[C:12]([C:13]=1[OH:14])=[C:11]([CH3:15])[CH:10]=[CH:9][CH:8]=2)([CH3:3])[CH3:2].[C:18](OC(=O)C)(=[O:20])[CH3:19].O>N1C=CC=CC=1>[C:18]([O:14][C:13]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][C:11]=2[CH3:15])[C:6]([CH:16]=[O:17])=[CH:5][C:4]=1[CH:1]([CH3:3])[CH3:2])(=[O:20])[CH3:19]

Participants

5

Reactant 3

HCID 962WaterHCID 7918Acetic AnhydrideHCID 14986465HCID 14986465, compound

Product 1

HCID 14986466HCID 14986466, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

0.7 g of 3-isopropyl-4-hydroxy-5-methyl-1-naphthalenecarbaldehyde and 10 ml of acetic anhydride were dissolved in 10 ml of pyridine and reacted at room temperature for 1 hour. The reaction solution was poured into water and extracted with ethyl acetate. The organic phase was washed with dilute hydrochloric acid, a saturated sodium hydrogencarbonate aqueous solution and a saturated saline solution in this order, dried with anhydrous magnesium sulfate and concentrated under reduced pressure, thereby obtaining 0.5 g of the captioned compound as a black oily substances.

Workup

  1. customreacted at room temperature for 1 hour
  2. extractionextracted with ethyl acetate
  3. washThe organic phase was washed with dilute hydrochloric acid
  4. dry with materiala saturated sodium hydrogencarbonate aqueous solution and a saturated saline solution in this order, dried with anhydrous magnesium sulfate
  5. concentrationconcentrated under reduced pressure

Sources & evidence

ORD record
ord-efa831f985b4474bbd7312e891c08906
Source dataset
uspto-grants-1992_07
Patent number
US05134111

Reaction notes

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