Acetic Anhydride → HCID 22401893, compound

HRID 654717Notes

Reaction equation

HRID 654717 reaction equation
[OH:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][C:10]=2[CH2:12][CH2:13][CH3:14])[C:5](/[CH:15]=[C:16](\[CH3:20])/[C:17]([OH:19])=[O:18])=[CH:4][C:3]=1[O:21][CH3:22].[C:23](OC(=O)C)(=[O:25])[CH3:24]>N1C=CC=CC=1>[C:23]([O:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][C:10]=2[CH2:12][CH2:13][CH3:14])[C:5](/[CH:15]=[C:16](\[CH3:20])/[C:17]([OH:19])=[O:18])=[CH:4][C:3]=1[O:21][CH3:22])(=[O:25])[CH3:24]

Participants

4

Reactant 2

HCID 7918Acetic AnhydrideHCID 10086171HCID 10086171, compound

Product 1

HCID 22401893HCID 22401893, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

7.1 g of (E)-3-(4-hydroxy-3-methoxy-5-propyl-1-naphthyl)-2-methylpropenoic acid was dissolved in 20 ml of pyridine and 2 ml of acetic anhydride was added, followed by stirring at room temperature overnight. The reaction mixture was concentrated in vacuo and the resultant crystals were filtered and washed with ethyl acetate to obtain 7.5 g of the titled compound as colorless crystals.

Workup

  1. concentrationThe reaction mixture was concentrated in vacuo
  2. filtrationthe resultant crystals were filtered
  3. washwashed with ethyl acetate

Sources & evidence

ORD record
ord-855c0ac333e6469c90c061418dd48dc7
Source dataset
uspto-grants-1992_07
Patent number
US05134111

Reaction notes

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