HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Piperidinecarboxylic acid → 1-(Benzocyclobuten-1-ylmethyl)-4-piperidinecarboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Piperidinecarboxylic acid | HCID 3773 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 7-(Iodomethyl)bicyclo[4.2.0]octa-1,3,5-triene | HCID 2763023 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 1-(Benzocyclobuten-1-ylmethyl)-4-piperidinecarboxylic acid | HCID 19886372 | — |
Reaction Steps
0.028 mole of 1-(iodomethyl)benzocyclobutene (Process 1, stage G}, 0.028 mole of 4-piperidinecarboxylic acid and 0.028 mole of triethylamine are mixed in 95 ml of dimethylformamide. The mixture is brought to 60° C. for 6 hours. It is evaporated to dryness, the residue is taken up with ethyl acetate and water and settling is allowed to take place.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05134147 |
| Source dataset | uspto-grants-1992_07 |
| ORD ID | ord-0cdb44d54758404eaf35ad6906845220 |
| Source note | uspto-grants-1992_07 |