1,1'-Carbonyldiimidazole → HCID 19886429, compound

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Reaction Steps

8.0 g of 4,5-dimethoxybenzocyclobutene-1-carboxylic acid (prepared according to the process described in Tetrahedron (1973) 29 p. 73) are dissolved in 130 ml of tetrahydrofuran, and 6.9 g of carbonyldiimidazole are added. The mixture is stirred at room temperature for 2 hours until the gaseous evolution has ceased. A solution of 8.5 g of 6-fluoro-3-piperid-4-yl-1,2-benzisoxazole in 100 ml of tetrahydrofuran is then added dropwise. The mixture is stirred at room temperature overnight. The expected product precipitates. It is filtered off and dried in a desiccator over phosphorus pentoxide.

Provenance & Evidence