HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzene → HCID 47240101, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzene | HCID 241 | — |
| Reactant | Cyanoacetic acid | HCID 9740 | — |
| Reactant | Ammonium Acetate | HCID 517165 | — |
| Reactant | 2,3-Dihydrobenzofuran-5-carboxaldehyde | HCID 735901 | — |
| Solvent | Hydrochloric Acid | HCID 313 | — |
| Solvent | Pyridine | HCID 1049 | — |
| Product | HCID 47240101 | HCID 47240101 | — |
Reaction Steps
39.5 g of 2,3-dihydro-5-benzofurancarbaldehyde (prepared according to the process described in J. Org. Chem. (1984), 49, p. 409), 22.7 g of 2-cyanoacetic acid and 4.08 g of ammonium acetate are mixed in 37 ml of pyridine and 210 ml of benzene The mixture is brought to reflux for 6 hours 30 minutes. The precipitate formed is isolated and then suspended in 600 ml of 6 N hydrochloric acid. The solid isolated is filtered off and washed with water and dried in the air.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05134147 |
| Source dataset | uspto-grants-1992_07 |
| ORD ID | ord-8c939b57d5024b61ae17178ad9838c82 |
| Source note | uspto-grants-1992_07 |