反应详情

A mixture of 4,5-dihydro-1-(4-fluorophenyl)-5-[4-(methylthio)phenyl]pyrazol-3-amine (1 g) and manganese (IV) oxide (1.16 g) in dichloromethane (100 ml) was stirred at ambient temperature for 2 hours. The insoluble was filtered and the filtrate was concentrated to dryness. The residue (1 g) was purified by column chromatography on silica gel (16 g) eluting with a mixture of chloroform and ethyl acetate (5:1 to give a pale brown powder of 1-(4-fluorophenyl)-5-[4-(methylthio)phenyl]pyrazol-3-amine (0.64 g).

1. filtrationThe insoluble was filtered
2. concentrationthe filtrate was concentrated to dryness
3. customThe residue (1 g) was purified by column chromatography on silica gel (16 g)
4. washeluting with a mixture of chloroform and ethyl acetate (5:1