Hydrochloric Acid → HCID 10498716, compound

Participants

Reaction Steps

A mixture of ethyl 1-(4-fluorophenyl)-5-[4-(methylsulfonyl)phenyl]pyrazole-3-carboxylate (4.4 g) and 4N sodium hydroxide (5.7 ml) in tetrahydrofuran (20 ml), ethanol (10 ml and dioxane 20 ml was stirred at ambient temperature overnight. Water (50 ml) was added, and the mixture was acidified with hydrochloric acid. The precipitates were filtered and washed with water to give colorless crystals of 1-(4-fluorophenyl)-5-[4-(methylsulfonyl)phenyl]pyrazole-3-carboxylic acid (4.1 g).

Provenance & Evidence