Dimethylamine, hydrochloride → HCID 19886178, compound

Participants

Reaction Steps

A mixture of 1-(4-fluorophenyl)-5-[4-(methylthio)phenyl]pyrazole-3-carboxylic acid (3 g) and 1,1'-carbonyldiimidazole (1.6 g) in tetrahydrofuran (39 ml) was refluxed for 1 hour. Dimethylamine hydrochloride (1.04 g) and potassium carbonate (1.33 g) were added, and the resulting mixture was stirred and refluxed for 3 hours. The mixture was diluted with ethyl acetate, washed with water, an aqueous solution of sodium bicarbonate, dilute hydrochloric acid and water, successively, dried and concentrated to give a pale brown oil of 1-(4-fluorophenyl)-N,N-dimethyl-5-[4-(methylthio)phenyl]pyrazole-3-carboxamide (2.6 g).

Provenance & Evidence