Hydrogen iodide → HCID 19886245, compound

Participants

Reaction Steps

A mixture of ethyl 1-(4-methoxyphenyl)-5-[4-(methylsulfonyl)phenyl]pyrazole-3-carboxylate (2 g) and hydriodic acid (57%, 5 ml) in acetic acid (10 ml) was refluxed for 5 hours. The reaction mixture was concentrated and the residue was triturated in an aqueous solution of sodium bisulfite giving a powder. This crude powder was purified by column chromatography on silica gel (80 g) eluting with a mixture of chloroform and methanol to give a powder of 1-(4-hydroxyphenyl)-5-[4-(methylsulfonyl)phenyl]pyrazole-3-carboxylic acid (0.86 g).

Provenance & Evidence