Pyridine → HCID 10810357, compound

Participants

Reaction Conditions

Reaction Steps

Methyl chloroformate (0.163 ml) in acetonitrile (0.7 ml) was added dropwise to a stirred solution of 1-(4-fluorophenyl)-5-[4-(methylsulfonyl)phenyl]pyrazole-3-amine (0.7 g) and pyridine (0.171 ml) in acetonitrile (6 ml) and tetrahydrofuran (7 ml) at -20° C. The mixture was stirred at 5° C. for 1 hour, diluted with ethyl acetate, washed with water, dried, and concentrated. The residue (0.9 g) was recrystallized from a mixture of chloroform and ethanol to give pale brown crystals of methyl N-{1-(4-fluorophenyl)-5-[4-(methylsulfonyl)phenyl]-3-pyrazolyl}carbamate (0.51 g).

Provenance & Evidence