Formic Acid → HCID 19886107, compound

HRID 654799Notes

Reaction equation

HRID 654799 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[C:12]([C:13]3[S:14][C:15]([S:18]([CH3:21])(=[O:20])=[O:19])=[CH:16][CH:17]=3)=[CH:11][C:10]([C:22]#[N:23])=[N:9]2)=[CH:4][CH:3]=1.[CH:24](O)=[O:25]>>[CH:24]([NH:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[C:12]([C:13]3[S:14][C:15]([S:18]([CH3:21])(=[O:20])=[O:19])=[CH:16][CH:17]=3)=[CH:11][C:10]([C:22]#[N:23])=[N:9]2)=[CH:4][CH:3]=1)=[O:25]

Participants

3

Reactant 2

HCID 284Formic AcidHCID 19886100HCID 19886100, compound

Product 1

HCID 19886107HCID 19886107, compound

Procedure

A mixture of 1-(4-aminophenyl)-5-[5-(methylsulfonyl)-2-thienyl]pyrazole-3-carbonitrile (1.1 g) and formic acid (5 ml) was refluxed for 30 minutes. The mixture was concentrated and the residue was triturated in water to give crystals of 1-[4-(formylamino)phenyl]-5-[5-(methylsulfonyl)-2-thienyl]pyrazole-3-carbonitrile (1.1 g).

Workup

  1. temperaturewas refluxed for 30 minutes
  2. concentrationThe mixture was concentrated
  3. customthe residue was triturated in water

Sources & evidence

ORD record
ord-e49be0670fa542e7a475837e5082de3f
Source dataset
uspto-grants-1992_07
Patent number
US05134142

Reaction notes

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