Hydrochloric Acid → HCID 57288043, compound

Participants

Reaction Conditions

Reaction Steps

A solution of 1-[4-(formylamino)phenyl]-5-[5-(methylsulfonyl)-2-thienyl]pyrazole-3-carbonitrile (1.1 g) in N,N-dimethylformamide (3 ml) was added dropwise to a suspension of sodium hydride (60%; 118 mg) in N,N-dimethylformamide (2 ml). The mixture was stirred at 0° C. for 30 minutes. To the mixture was added dropwise a solution of iodomethane (0.84 g) in N,N-dimethylformamide (2 ml) at 0° C. The resulting mixture was stirred at 0° C. for 1 hour, poured into an ice-cooled dilute hydrochloric acid, and extracted with ethyl acetate. The extract was washed with water, dried over magnesium sulfate, and evaporated in vacuo. The residue was recrystallized from ethanol to give crystals of 1-[4-(N-formylmethylamino)phenyl]-5-[5-(methylsulfonyl)-2-thienyl]pyrazole -3-carbonitrile (1 g).

Provenance & Evidence