4-Fluorophenylhydrazine hydrochloride → HCID 23174220, compound

Participants

Reaction Steps

A mixture of 4-fluoro-1-[4-(methylthio)phenyl]butan-1,3-dione (2 g) and 4-fluorophenylhydrazine hydrochloride (1.6 g) in acetic acid (10 ml) was refluxed for 5 hours. The solvent was evaporated and the residue was dissolved in ethyl acetate. The resulting solution was washed with an aqueous solution of sodium bicarbonate, dried, and concentrated in vacuo. The residue (3 g) was purified by column chromatography on silica gel eluting with chloroform. An oil of 3-(chloromethyl)-1-(4-fluorophenyl) -5-[4-(methylthio)phenyl]pyrazole (1.3 g) was obtained from the first eluate.

Provenance & Evidence