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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 654813Generated: October 29, 2026

6-(Bromomethyl)-1-methylquinolin-2(1H)-one → 4-[3-(1,2-Dihydro-1-methyl-2-oxoquinolin-6-ylmethoxy)phenyl]-4-methoxy-2,2-dimethyltetrahydropyran

https://huagongshe.com/reaction/654813

Reaction equation

Participants

RoleNameHCIDCharge
Reactant6-(Bromomethyl)-1-methylquinolin-2(1H)-oneHCID 15199065—
Reactant4-(3-Hydroxyphenyl)-4-methoxy-2,2-dimethyltetrahydropyranHCID 20080655—
Product4-[3-(1,2-Dihydro-1-methyl-2-oxoquinolin-6-ylmethoxy)phenyl]-4-methoxy-2,2-dimethyltetrahydropyranHCID 5728156583%

Reaction Steps

Using the procedure described in Example 1, 6-bromomethyl-1,2-dihydro-1-methylquinolin-2-one was reacted with 4-(3-hydroxyphenyl)-4-methoxy-2,2-dimethyltetrahydropyran to give 4-[3-(1,2-dihydro-1-methyl-2-oxoquinolin-6-ylmethoxy)phenyl]-4-methoxy-2,2-dimethyltetrahydropyran in 83% yield.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS05134148
Source datasetuspto-grants-1992_07
ORD IDord-6c9bdf60e0a945f6b39704d0611b93bc
Source noteuspto-grants-1992_07