Methyl iodide → HCID 57284075, compound

HRID 654817Notes

Reaction equation

[CH3:1][N:2]1[C:11]2[C:6](=[CH:7][C:8]([CH2:12][O:13][C:14]3[CH:15]=[C:16]([C:24]4([OH:30])[CH2:29][CH2:28][O:27][CH2:26][CH2:25]4)[CH:17]=[C:18]([C:20]([F:23])([F:22])[F:21])[CH:19]=3)=[CH:9][CH:10]=2)[CH:5]=[CH:4][C:3]1=[O:31].[CH3:32]I>>[CH3:1][N:2]1[C:11]2[C:6](=[CH:7][C:8]([CH2:12][O:13][C:14]3[CH:15]=[C:16]([C:24]4([O:30][CH3:32])[CH2:25][CH2:26][O:27][CH2:28][CH2:29]4)[CH:17]=[C:18]([C:20]([F:21])([F:22])[F:23])[CH:19]=3)=[CH:9][CH:10]=2)[CH:5]=[CH:4][C:3]1=[O:31]

Participants

Reactant 2

HCID 6328Methyl iodide

HCID 57113227HCID 57113227, compound

Product 1

HCID 57284075HCID 57284075, compoundYield 95%

Procedure

Using the procedure described in Example 11, 4-[3-(1,2-dihydro-1-methyl-2-oxoquinolin-6-ylmethoxy)-5-trifluoromethylphenyl]-4-hydroxytetrahydropyran was reacted with methyl iodide to give 4-[3-(1,2-dihydro-1-methyl-2-oxoquinolin-6-ylmethoxy)-5-trifluoromethylphenyl]-4-methoxytetrahydropyran in 95% yield, m.p. 103° C.

Sources & evidence

ORD record: ord-9a5b056e913c4c3f8876eaeb1a0dfb33
Source dataset: uspto-grants-1992_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05134148

Reaction notes

Loading…