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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 654818Generated: October 30, 2026

6-(Bromomethyl)-1-methylquinolin-2(1H)-one → (3RS,4SR)-4-[3-(1,2-dihydro-1-methyl-2-oxoquinolin-6-ylmethoxy)phenyl]-3-hydroxy-4-methoxytetrahydropyran

https://huagongshe.com/reaction/654818

Reaction equation

Participants

RoleNameHCIDCharge
Reactant6-(Bromomethyl)-1-methylquinolin-2(1H)-oneHCID 15199065—
Reactant(3RS,4SR)-3-hydroxy-4-(3-hydroxyphenyl)-4-methoxytetrahydropyranHCID 67796247—
Product(3RS,4SR)-4-[3-(1,2-dihydro-1-methyl-2-oxoquinolin-6-ylmethoxy)phenyl]-3-hydroxy-4-methoxytetrahydropyranHCID 6779658584%

Reaction Steps

Using the procedure described in Example 1, 6-bromomethyl-1,2-dihydro-1-methylquinolin-2-one was reacted with (3RS,4SR)-3-hydroxy-4-(3-hydroxyphenyl)-4-methoxytetrahydropyran to give (3RS,4SR)-4-[3-(1,2-dihydro-1-methyl-2-oxoquinolin-6-ylmethoxy)phenyl]-3-hydroxy-4-methoxytetrahydropyran in 84% yield, m.p. 62°-66° C.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS05134148
Source datasetuspto-grants-1992_07
ORD IDord-2593f6a46920499bb88f31f8b763459d
Source noteuspto-grants-1992_07