Sodium hydride → HCID 57321239, compound

Participants

Reaction Steps

28 mg (1.003 mmole) of sodium hydride (as a 60% w/w dispersion in mineral oil) was added, whilst ice-cooling, to a solution of 200 mg (0.59 mmole) of (2R*,3S*,4S*)-2-(4-chlorophenyl)-3-methyl-4-methanesulfonyloxy-1-(1H-1,2,4-triazol-1-yl)pentanol in 5 ml of dimethylformamide, and the resulting mixture was stirred for 1.5 hours. At the end of this time, the reaction mixture was treated in a similar manner to that described in Example 60, to afford 32.3 mg (yield 19.7%) of the title compound as an oil.

Provenance & Evidence