Methanesulfonyl chloride → HCID 57114966, compound

Participants

Reaction Steps

140 mg (1.22 mmole) of methanesulfonyl chloride were added at 0° C. to a solution of 213 mg (0.72 mmole) of (2R*,3S*,4S*)-2-(2,4-difluorophenyl)-3-methyl-1-(1H-1,2,4-triazol-1-yl)-2,4-pentanediol [prepared as described in step (b) above] in 4 ml of pyridine, and the mixture was stirred for 2.5 hours. At the end of this time, the pyridine was removed by distillation under reduced pressure. The resulting residue was mixed with a dilute aqueous solution of sodium hydrogencarbonate and extracted with ethyl acetate. The extract was dried over anhydrous sodium sulfate and freed from the solvent by evaporation under reduced pressure, to afford 270 mg of the title compound as an oil.

Provenance & Evidence