Water → HCID 57296556, compound

Participants

Reaction Steps

53 mg (1.40 mmole) of lithium aluminum hydride were added, under an atmosphere of nitrogen, to a solution of 207 mg (0.70 mmole) of (2R*,3R*)-2-(2,4-difluorophenyl)-4,5-epoxy-3-methyl-1-(1H-1,2,4-triazol-1-yl)-2-pentanol [about a 3:1 mixture of isomers at the C4 position, prepared as described in Preparation 3] in 4 ml of diethyl ether, whilst ice-cooling and stirring. Ten minutes later the reaction mixture was heated under reflux, and this was continued for 1 hour. At the end of this time, the mixture was cooled, and 1 ml of water was slowly added, after which the mixture was stirred for 10 minutes. The insoluble materials were removed by filtration using a Celite filter aid, after which the residue was washed with ethyl acetate. The combined filtrate and washings were dried over anhydrous sodium sulfate, and the solvent was removed by distillation under reduced pressure. The resulting oily residue was subjected to column chromatography through silica gel, using a 5:5:1 by volume mixture of ethyl acetate, chloroform and hexane as the eluent, to afford 160 mg of the title compound.

Provenance & Evidence