HCID 86746022, compound → HCID 53783140, compound

Participants

Reaction Steps

N-[2-[[(6-Phenylmethoxy-2-benzofuranyl)methyl]amino]ethyl]tricyclo[3.3.1.13,7 ]decane-1-carboxamide (4.74 g, 10 mmole) was dissolved in 100 ml of ethanol and 1.0 g of 10% palladium on carbon was added. The mixture was hydrogenated at 50 psi on a Parr apparatus overnight. The mixture was then filtered through celite and concentrated in vacuum. The residue was column chromatographed on 100 g of silica gel using 5% methanol/chloroform as eluant and the crude product thus obtained was crystallized from 15 ml of ethanol with the addition of 8 ml of 4N HCl/isopropanol and 100 ml of diethyl ether to give 1.6 g of the title compound as a white solid, monohydrochloride, quarter hydrate, m.p. 136°-139° C.

Provenance & Evidence