Acetic Anhydride → HCID 15723360, compound

Participants

Reaction Steps

A mixture of 4-(1-hydroxyundecyl)-2-trimethylsilylfuran (1.21 g, 3.89 mmol), acetic anhydride (4 ml) and pyridine (6 ml) was stirred under argon at ca. 20° for 14h. After most of the solvent was removed under high vacuum (<40°), the residue was dissolved in ether (40 ml) and washed thoroughly with aqueous copper sulfate and water. Drying (magnesium sulfate) and evaporation gave a brown oil, which was flash chromatographed on silica using 5% ethyl ether/petroleum ether. Fractions with Rf of about 0.3 on evaporation afforded the captioned compound as a pale yellow oil.

Provenance & Evidence