Ammonia → Ethyl 6-amino-8-methoxycarbonyl-4-oxo-10-propyl-4H-pyrano[3,2-g]quinoline-2-carboxylate

HRID 65492Notes

Reaction equation

HRID 65492 reaction equation
[CH3:1][O:2][C:3]([C:5]1[CH:14]=[C:13]([NH:15]C(=O)C(Cl)(Cl)Cl)[C:12]2[C:7](=[C:8]([CH2:32][CH2:33][CH3:34])[C:9]3[O:25][C:24]([C:26]([O:28][CH2:29][CH3:30])=[O:27])=[CH:23][C:22](=[O:31])[C:10]=3[CH:11]=2)[N:6]=1)=[O:4].N>S(=O)(=O)(O)O>[NH2:15][C:13]1[C:12]2[C:7](=[C:8]([CH2:32][CH2:33][CH3:34])[C:9]3[O:25][C:24]([C:26]([O:28][CH2:29][CH3:30])=[O:27])=[CH:23][C:22](=[O:31])[C:10]=3[CH:11]=2)[N:6]=[C:5]([C:3]([O:2][CH3:1])=[O:4])[CH:14]=1

Participants

4

Reactant 2

HCID 222AmmoniaHCID 20233204HCID 20233204, compound

Product 1

HCID 13544003Ethyl 6-amino-8-methoxycarbonyl-4-oxo-10-propyl-4H-pyrano[3,2-g]quinoline-2-carboxylate

Reagents, catalysts & solvents 1

HCID 1118Sulfuric AcidSolvent

Procedure

The product of step (a) (1.0 g) was dissolved in concentrated sulphuric acid (1 ml) and stirred vigorously for 0.5 hours. The deep rep solution was then poured into iced aqueous ammonia solution (100 ml), and the precipitate filtered to give the title compound, 0.5 g, as an orange powder, mp 265°-270° C. (decomposes).

Workup

  1. filtrationthe precipitate filtered

Sources & evidence

ORD record
ord-ba357442107f4f52810a11c3934023a5
Source dataset
uspto-grants-1986_09
Patent number
US04614802

Reaction notes

Loading…