Acetic Anhydride → HCID 19885973, compound

HRID 654940Notes

Reaction equation

HRID 654940 reaction equation
[OH:1][CH:2]([C:18]1[CH:22]=[C:21]([Si:23]([CH3:26])([CH3:25])[CH3:24])[O:20][CH:19]=1)[CH2:3][CH2:4][CH2:5][CH:6]([C:8]1[CH:17]=[CH:16][C:15]2[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=2)[CH:9]=1)[CH3:7].[C:27](OC(=O)C)(=[O:29])[CH3:28]>N1C=CC=CC=1>[C:27]([O:1][CH:2]([C:18]1[CH:22]=[C:21]([Si:23]([CH3:25])([CH3:24])[CH3:26])[O:20][CH:19]=1)[CH2:3][CH2:4][CH2:5][CH:6]([C:8]1[CH:17]=[CH:16][C:15]2[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=2)[CH:9]=1)[CH3:7])(=[O:29])[CH3:28]

Participants

4

Reactant 2

HCID 7918Acetic AnhydrideHCID 19885976HCID 19885976, compound

Product 1

HCID 19885973HCID 19885973, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

A mixture of 3-[1-hydroxy-5-(2-napthyl)hexyl]-5-trimethylsilylfuran (120 mg, 0.3 mmol) and acetic anhydride (66 mg, 651 mmol) in pyridine (1.3 ml) was stirred at room temperature overnight. After removal of the solvent, the residue was purified by preparative TLC (20×20 cm, 500μ silica gel plate; developed with 30% ethyl ether/hexane) yielding the title compound as a yellow oil.

Workup

  1. customAfter removal of the solvent
  2. customthe residue was purified by preparative TLC (20×20 cm, 500μ silica gel plate; developed with 30% ethyl ether/hexane)

Sources & evidence

ORD record
ord-e970ac857f3940c190a2bd2b710424a4
Source dataset
uspto-grants-1992_07
Patent number
US05134128

Reaction notes

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