HuagongsheHuagongshe Chemistry Print Report · For research reference only
Chloroform → Dicyclohexylcarbodiimide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Chloroform | HCID 6212 | — |
| Reactant | Acetonitrile | HCID 6342 | — |
| Reactant | Dichloromethane | HCID 6344 | — |
| Reactant | Tetrahydrofuran | HCID 8028 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Catalyst | 4-(Dimethylamino)pyridine | HCID 14284 | — |
| Solvent | Pyridine | HCID 1049 | — |
| Product | Dicyclohexylcarbodiimide | HCID 10868 | — |
Reaction Steps
The resulting compound was then reacted with a compound of formula X--R20, wherein X represents a halogen atom, in an organic solvent, e.g., methylene chloride, chloroform, acetonitrile, tetrahydrofuran, etc., in the presence of an organic base, e.g., pyridine, 4-dimethylamino pyridine, triethylamine, etc., or reacted with a compound of the formula HO-R20 and a catalyst such as dicyclohexylcarbodiimide in the presence of 4-dimethylaminopyridine to obtain the compound of formula (V').
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05134230 |
| Source dataset | uspto-grants-1992_07 |
| ORD ID | ord-a3395af376dd4a2baec855284a7f039c |
| Source note | uspto-grants-1992_07 |