Ketene → HCID 178468091, compound

Participants

Reaction Steps

p-Nitrobenzyl 3-benzylamino-4-methyl-5-phenylthio-2-pentenoate (505 mg; 1 mmole) was dissolved in toluene (5 ml), and gaseous ketene was introduced therein at room temperature. After completion of the reaction, the solvent was removed under reduced pressure, and the residue was purified by silica gel column chromatography to give p-nitrobenzyl 2-acetyl-3-benzylamino-4-methyl-5-phenylthio-2-pentenoate.

Provenance & Evidence