Water → HCID 178500781, compound

Participants

Reaction Steps

Dimethyl acetonedicarboxylate (50 g; 0.29 mmole) was dissolved in toluene (150 ml), and benzylamine (32.2 g; 0.3 mmole) was added thereto. The resultant mixture was heated under reflux for 30 minutes while elimination of water and then cooled to room temperature. Gaseous ketene was introduced therein. The precipitated crystals were collected by filtration and recrystallized from ethanol to give dimethyl 2-acetyl-3-benzylamino-2-pentenedioate. M.P., 123.5°-124.0° C.

Provenance & Evidence