Barium hydroxide → HCID 14348570, compound

Participants

Reaction Steps

Ethyl (2SR,3SR,4RS,5RS)-tetrahydro-2,5-dimethyl-6-oxo-4-benzylamino-2H-pyrane-3-carboxylate (3 mg) and barium hydroxide (7 mg) were dissolved in a mixture of tetrahydrofuran and water (2:1) and stirred vigorously at room temperature for 1 hour. The reaction mixture was treated as in Reference Example 17 to give (2RS,3RS,4SR,5SR)-2-methyl-3-benzylamino-4-ethoxycarbonyl-5-hydroxyhexanoic acid.

Provenance & Evidence