HCID 86746018, compound → HCID 14348567, compound

Participants

Reaction Steps

Methyl (2SR,3SR,4RS,5RS)-tetrahydro-2,5-dimethyl-6-oxo-4-benzylamino-2H-pyrane-3-carboxylate hydrochloride (110 mg) was dissolved in conc. hydrochliric acid (0.9 ml), and the resultant mixture was refluxed for 2 hours. After cooling, the reaction mixture was diluted with ethanol and distilled under reduced pressure. The residue was purified by thin layer chromatography to give (2SR,3SR,4RS,5RS)-tetrahydro-2,5-dimethyl-6-oxo-4-benzylamino-2H-pyrane-3-carboxylic acid.

Provenance & Evidence