Ammonia → 7-[(2-Amino-1-hydroxy-2-phenylethylidene)amino]-3-chloro-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid--water (1/1)

Participants

Reaction Steps

A crystallisation reactor was filled with 34 g water and 1.0 g cefaclor as seed. The above-mentioned acidic cefaclor solution was dosed into the crystallisation reactor in 60 minutes at 35° C. The pH was kept at 5.0 with ammonia. Subsequently, the temperature was lowered in steps: 30 min at 30° C., 30 min at 25° C., and 60 min at 20° C. The suspension was filtered through a glass filter and the wet cake was washed with one volume of water and two volumes of acetone. After drying, 15.7 g cefaclor monohydrate was obtained (purity 99.4%).

Provenance & Evidence