Ammonia → 7-[(2-Amino-1-hydroxy-2-phenylethylidene)amino]-3-chloro-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid--water (1/1)

Participants

Reaction Conditions

Reaction Steps

A crystallisation reactor was filled with 10 g water. The above-mentioned acidic cefaclor solution was dosed into the crystallisation reactor in 30 minutes at 25° C. The pH was kept at 5.0 with ammonia. Subsequently, the suspension was stirred at 10° C. for another 30 min. The suspension was filtered through a glass filter and the wet cake was washed with 2×15 ml water and 2×15 ml acetone. After drying, 18.3 g cefaclor monohydrate was obtained (purity 99.6%).

Provenance & Evidence