4,4'-(2-Aminoethylidene)bisphenol → HCID 86761446, compound

HRID 655124Notes

Reaction equation

HRID 655124 reaction equation
C([O:4][C@@H:5]1[C@@H:9]([C:10]2[O:14][N:13]=[C:12]([CH2:15][O:16]C(=O)C)[CH:11]=2)[O:8][C@@H:7]([N:20]2[CH:28]=[N:27][C:26]3[C:21]2=[N:22][C:23]([Cl:30])=[N:24][C:25]=3Cl)[C@@H:6]1[O:31]C(=O)C)(=O)C.[NH2:35][CH2:36][CH:37]([C:45]1[CH:50]=[CH:49][C:48]([OH:51])=[CH:47][CH:46]=1)[C:38]1[CH:43]=[CH:42][C:41]([OH:44])=[CH:40][CH:39]=1>>[OH:44][C:41]1[CH:42]=[CH:43][C:38]([CH:37]([C:45]2[CH:46]=[CH:47][C:48]([OH:51])=[CH:49][CH:50]=2)[CH2:36][NH:35][C:25]2[N:24]=[C:23]([Cl:30])[N:22]=[C:21]3[C:26]=2[N:27]=[CH:28][N:20]3[C@H:7]2[C@H:6]([OH:31])[C@H:5]([OH:4])[C@@H:9]([C:10]3[O:14][N:13]=[C:12]([CH2:15][OH:16])[CH:11]=3)[O:8]2)=[CH:39][CH:40]=1

Participants

3

Reactant 2

HCID 217102804,4'-(2-Aminoethylidene)bisphenol2×HCID 86761447HCID 86761447, compound

Product 1

HCID 86761446HCID 86761446, compound

Procedure

The title compound is prepared from acetic acid (2R,3R,4R,5S)-4-acetoxy-5-(3-acetoxymethyl-isoxazol-5-yl)-2-(2,6-dichloro-purin-9-yl)-tetrahydro-furan-3-yl ester (WO 99/38877) analogously to (2R,3R,4S,5S)-2-[2-chloro-6-(2,2-diphenyl-ethylamino)-purin-9-yl]-5-(3-hydroxymethyl-isoxazol-5-yl)-tetrahydro-furan-3,4-diol (Intermediate CG) by replacing 2,2-diphenylethylamine with 4,4′-(2-aminoethylidene)bisphenol (Intermediate A).

Sources & evidence

ORD record
ord-3538dcc5a38f41d6a5ab7c6d7162e663
Source dataset
uspto-grants-2011_12
Patent number
US08071565B2

Reaction notes

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