反应详情

To a solution of 3-(2-pyridyl)cyclopentan-1-one (3.17 g, 19.7 mmol) in MeOH (80 ml) was added portionwise NaBH4 (745 mg. 19.7 mmol) at 0° C., and stirred for 2 h at room temperature. The reaction mixture was poured into ice-water and then extracted with EtOAc. The organic layer was dried over anhyd Na2SO4 followed by the removal of solvent. The crude product was purified by column chromatography (Hexane/EtOAc=1/1→1/3) to yield cis-3-(2-pyridyl)cyclopentanol (1.90 g, 59%) as colorless oil.

1. extractionextracted with EtOAc
2. dry with materialThe organic layer was dried over anhyd Na2SO4
3. customfollowed by the removal of solvent
4. customThe crude product was purified by column chromatography (Hexane/EtOAc=1/1→1/3)