反应详情

A mixture of (1R,3R)-N-[3-(2-pyridyl)cyclopentyl]phthalimide (4.17 g, 14.3 mmol), and hydrazinemonohydorate (2.0 mL, 41.2 mmol) in EtOH (100 mL) was stirred at reflux for 4 h. After cooling, the reaction mixture was filtered followed by the removal of solvent. The residue was suspended in EtOAc and stirred at reflux for 1 h. After cooling, the precipitate was filtered followed by the removal of solvent to yield (1R,3R)-3-(2-pyridyl)cyclopentylamine (1.62 g, 70%) as yellow oil.

1. temperatureat reflux for 4 h
2. temperatureAfter cooling
3. filtrationthe reaction mixture was filtered
4. customfollowed by the removal of solvent
5. stirringstirred
6. temperatureat reflux for 1 h
7. temperatureAfter cooling
8. filtrationthe precipitate was filtered
9. customfollowed by the removal of solvent