trans-3-(2-Pyridyl)cyclopentylamine → cis-3-(2-Pyridyl)cyclopentylamine

HRID 655146Notes

Reaction equation

HRID 655146 reaction equation
[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[C@@H:7]1[CH2:11][CH2:10][C@H:9]([N:12]2C(=O)C3=CC=CC=C3C2=O)[CH2:8]1.N1C=CC=CC=1[C@H]1CC[C@H](N)C1>>[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[C@@H:7]1[CH2:11][CH2:10][C@H:9]([NH2:12])[CH2:8]1

Participants

3

Reactant 2

HCID 59486146trans-3-(2-Pyridyl)cyclopentylamineHCID 67133552cis-N-[3-(2-pyridyl)cyclopentyl]phthalimide

Product 1

HCID 67133525cis-3-(2-Pyridyl)cyclopentylamineYield 99%

Procedure

The title compound (498 mg, 99%) was prepared from cis-N-[3-(2-pyridyl)cyclopentyl]phthalimide (905 mg, 3.10 mmol) in a manner similar to that described for the preparation of trans-3-(2-pyridyl)cyclopentylamine.

Sources & evidence

ORD record
ord-6df9eb44cde64698866d3a3224452bba
Source dataset
uspto-grants-2011_12
Patent number
US08071591B2

Reaction notes

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