反应详情

A mixture of trans-N-[3-(1H-pyrazol-1-yl)cyclopentyl]phthalimide (R) (1.49 g, 5.30 mmol), and hydrazinemonohydorate (0.51 mL, 10.5 mmol) in EtOH (30 mL) was stirred at reflux for 3 h. After cooling, the reaction mixture was filtered followed by the removal of solvent. The crude product was purified by column chromatography (Chromatrex, CH2Cl2/EtOH=30/1) to yield trans-3-(1H-pyrazol-1-yl)cyclopentylamine (517 mg, 65%) as yellow oil.

1. temperatureat reflux for 3 h
2. temperatureAfter cooling
3. filtrationthe reaction mixture was filtered
4. customfollowed by the removal of solvent
5. customThe crude product was purified by column chromatography (Chromatrex, CH2Cl2/EtOH=30/1)