Diisopropylethylamine → (3S)-8-amino-9-fluoro-2,3-dihydro-3-methyl-7-oxo-10-[trans-3-(1H-pyrazol-1-yl)cyclopentylamino]-7H-pyrido[1,2,3-de][1,4]benzoxazine-6-carbonitrile

HRID 655154Notes

Reaction equation

[NH2:1][C:2]1[C:15]2[C:14](=[O:16])[C:13]([C:17]#[N:18])=[CH:12][N:7]3[C@@H:8]([CH3:11])[CH2:9][O:10][C:5]([C:6]=23)=[C:4](F)[C:3]=1[F:20].[N:21]1([C@H:26]2[CH2:30][CH2:29][C@H:28]([NH2:31])[CH2:27]2)[CH:25]=[CH:24][CH:23]=[N:22]1.C(N(C(C)C)CC)(C)C>CS(C)=O>[NH2:1][C:2]1[C:15]2[C:14](=[O:16])[C:13]([C:17]#[N:18])=[CH:12][N:7]3[C@@H:8]([CH3:11])[CH2:9][O:10][C:5]([C:6]=23)=[C:4]([NH:31][C@H:28]2[CH2:29][CH2:30][C@H:26]([N:21]3[CH:25]=[CH:24][CH:23]=[N:22]3)[CH2:27]2)[C:3]=1[F:20]

Participants

Conditions

Temperature: 100 °C

Procedure

A mixture of (3S)-8-amino-9,10-difluoro-2,3-dihydro-3-methyl-7-oxo-7H-pyrido[1,2,3-de][1,4]benzoxazine-6-carbonitrile (702 mg, 2.53 mmol), trans-3-(1H-pyrazol-1-yl)cyclopentylamine (460 mg, 3.04 mmol) and di-isopropylethylamine (0.970 mL, 5.57 mmol) in anhydrous DMSO (14 mL) was stirred at 100° C. for 7 h. After cooling, the reaction mixture was poured into ice-water and then extracted with CH2Cl2-MeOH. The organic layer was washed with water and brine, and dried over anhyd Na2SO4 followed by the removal of solvent. The crude product was purified by column chromatography (Hexane/EtOAc=1/10→EtOAc) to yield (3S)-8-amino-9-fluoro-2,3-dihydro-3-methyl-7-oxo-10-[trans-3-(1H-pyrazol-1-yl)cyclopentylamino]-7H-pyrido[1,2,3-de][1,4]benzoxazine-6-carbonitrile (108 mg, 10%) as a yellow powder.

Workup

temperatureAfter cooling
extractionextracted with CH2Cl2-MeOH
washThe organic layer was washed with water and brine
dry with materialdried over anhyd Na2SO4
customfollowed by the removal of solvent
customThe crude product was purified by column chromatography (Hexane/EtOAc=1/10→EtOAc)

Sources & evidence

ORD record: ord-b4e2b6a3d4cd426cae477cd8ff3485a8
Source dataset: uspto-grants-2011_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08071591B2

Reaction notes

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