反应详情

A mixture of cis-N-[3-(3-pyridyl)cyclohexyl]phtalimide (1.64 g, 5.35 mmol) and hydrazinemonohydorate (0.52 mL, 10.7 mmol) in EtOH (25 mL) was stirred at room temperature for 2 h. The reaction mixture was filtered followed by the removal of solvent. The crude product was purified by column chromatography (NH, EtOAc) to yield cis-3-(3-pyridyl)cyclohexylamine (348 g, 37%) as colorless oil.

1. filtrationThe reaction mixture was filtered
2. customfollowed by the removal of solvent
3. customThe crude product was purified by column chromatography (NH, EtOAc)