Sodium Bicarbonate → HCID 59212058, compound

Participants

Reaction Steps

[Carboxymethyl-(3-phenoxyphenyl)amino]acetic acid 25 (5 g) was heated at reflux in acetic anhydride (30 mL) for 1 h. The cooled reaction mixture was poured into saturated aqueous sodium bicarbonate and extracted with ethyl acetate. The organic layer was washed several times with saturated aqueous sodium bicarbonate (until no further effervescence was observed) and twice with brine. The organic phase was dried (Na2SO4) and concentrated in vacuo to give the title compound as a golden oil (4.7 g, 100%). 1HNMR (300 MHz) (CDCl3) δ 6.10 (1H, m), 6.67 (2H, br d), 7.03 (2H, d), 7.17 (1H, t), 7.30 (1H, t) and 7.39 (2H, t).

Provenance & Evidence