反应详情

To a solution of amino-thiophen-2-yl-acetic acid (5 g) in formic acid (50 ml) was added acetic acid (18 ml). After stirring at room temperature for 6 h, water (25 ml) was added. The reaction mixture was stirred for 30 min. The mixture was concentrated in vacuo and triturated with water. The solids were collected by filtration and dried in vacuo (50° C.).

1. stirringThe reaction mixture was stirred for 30 min
2. concentrationThe mixture was concentrated in vacuo
3. customtriturated with water
4. filtrationThe solids were collected by filtration
5. customdried in vacuo (50° C.)