Acetic Acid → Formylamino-thiophen-2-yl-acetic acid

HRID 655198Notes

Reaction equation

HRID 655198 reaction equation
[NH2:1][CH:2]([C:6]1[S:7][CH:8]=[CH:9][CH:10]=1)[C:3]([OH:5])=[O:4].[C:11](O)(=[O:13])C.O>C(O)=O>[CH:11]([NH:1][CH:2]([C:6]1[S:7][CH:8]=[CH:9][CH:10]=1)[C:3]([OH:5])=[O:4])=[O:13]

Participants

5

Reactant 3

HCID 176Acetic AcidHCID 962WaterHCID 894352-Thiopheneacetic acid, alpha-amino-, (-)-

Product 1

HCID 21492681Formylamino-thiophen-2-yl-acetic acid

Reagents, catalysts & solvents 1

HCID 284Formic AcidSolvent

Procedure

To a solution of amino-thiophen-2-yl-acetic acid (5 g) in formic acid (50 ml) was added acetic acid (18 ml). After stirring at room temperature for 6 h, water (25 ml) was added. The reaction mixture was stirred for 30 min. The mixture was concentrated in vacuo and triturated with water. The solids were collected by filtration and dried in vacuo (50° C.).

Workup

  1. stirringThe reaction mixture was stirred for 30 min
  2. concentrationThe mixture was concentrated in vacuo
  3. customtriturated with water
  4. filtrationThe solids were collected by filtration
  5. customdried in vacuo (50° C.)

Sources & evidence

ORD record
ord-6d2f54b95a5640b48807c99fc7edca73
Source dataset
uspto-grants-2011_12
Patent number
US08071587B2

Reaction notes

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