Water → HCID 6931667, compound

HRID 655201Notes

Reaction equation

HRID 655201 reaction equation
[C:1](OC(=O)C)(=[O:3])C.[NH2:8][C@H:9]([C:14]([OH:16])=[O:15])[C:10]([CH3:13])([CH3:12])[CH3:11].O>ClCCl.C(O)=O>[CH:1]([NH:8][C@@H:9]([C:10]([CH3:13])([CH3:12])[CH3:11])[C:14]([OH:16])=[O:15])=[O:3]

Participants

6

Reactant 3

HCID 962WaterHCID 7918Acetic AnhydrideHCID 164608L-tert-Leucine

Product 1

HCID 6931667HCID 6931667, compound

Reagents, catalysts & solvents 2

HCID 284Formic AcidSolventHCID 6344DichloromethaneSolvent

Conditions

Temperature
0 °C

Procedure

A solution of acetic anhydride (18 ml) in dichloromethane (15 ml) was added drop wise to a cooled (0° C.) solution of L-tert-leucine (5 g) in formic acid (50 ml). The reaction mixture was stirred at 0° C. for 1 h and at room temperature for 3 h. Water (25 ml) was added. The mixture was stirred for another 30 min, concentrated in vacuo and co-evaporated twice with toluene. The remaining residue was triturated with diethyl ether. The solids were collected and dried in vacuo (50° C.).

Workup

  1. stirringThe mixture was stirred for another 30 min
  2. concentrationconcentrated in vacuo
  3. customThe remaining residue was triturated with diethyl ether
  4. customThe solids were collected
  5. customdried in vacuo (50° C.)

Sources & evidence

ORD record
ord-4301052650164476b023456ac425f0ea
Source dataset
uspto-grants-2011_12
Patent number
US08071587B2

Reaction notes

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