Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Ethylmorpholine → HCID 86761448, 화합물
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Ethylmorpholine | HCID 7525 | — |
| 반응물 | 2,3-Dimethoxyphenethylamine | HCID 137858 | — |
| 반응물 | O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate | HCID 2733207 | — |
| 반응물 | HCID 86761449 | HCID 86761449 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | HCID 86761448 | HCID 86761448 | — |
반응 단계
To a mixture of N-formyl-4-fluorophenylglycine (900 mg) and 2,3-dimethoxyphenethylamine (1 ml) in DMF (5 ml) was added N-ethylmorpholine (0.75 ml) and TBTU (1.6 g). After stirring for 4 h, the reaction was quenched by addition of water (30 ml). The product was extracted with ethylacetate. The organic layer was washed with water, dried (MgSO4), filtered and concentrated in vacuo. The residue was triturated with methyl-tert.butylether and recrystallized from toluene.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08071587B2 |
| 출처 데이터셋 | uspto-grants-2011_12 |
| ORD ID | ord-e1a2af46a098420786f22507da9aabc3 |
| 출처 메모 | uspto-grants-2011_12 |