Dimethylformamide → HCID 59320427, compound

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A mixture of 2-nitro-4-(6-phenyl-[1,2,4]triazolo[4,3-b]pyridazin-3-ylmethyl)-phenylamine (89 mg, 0.257 mmol) and 10% wt Pd/C (27 mg, 0.026 mmol) in methanol (4 mL), tetrahydrofuran (2 mL), and dimethylformamide (2 mL) was stirred at room temperature under hydrogen atmosphere for 4 h. Catalyst was filtered through celite and the filtrate was concentrated and dried in vacuo to provide 81 mg of the product as a beige solid. 1HNMR (DMSO) δ 4.30 (s, 2H), 4.32 (s, 2H), 4.43 (s, 2H), 6.43 (m, 2H), 6.50 (s, 1H), 7.60 (m, 3H), 7.93 (d, 1H), 8.11 (m, 2H), 8.39 (d, 1H); MS (m/z) 317 [M+H+]+.

Provenance & Evidence