Sodium Hydroxide → HCID 59320230, compound

Participants

Reaction Steps

0.5 g of (8-fluoro-quinolin-6-yl)-acetic acid tert-butyl ester with 2.0 ml of 4N aq. sodium hydroxide solution was heated at 90° C. for 3 h. After cooling the reaction mixture was extracted with ethyl acetate. The aqueous layer was made just acidic with acetic acid, filtered to afford the title compound as an off white solid (0.24 g, 61%). 1H NMR (300 MHz, DMSO-d6) δ 8.91˜8.93 (m, 1H), 8.37˜8.40 (m, 1H), 7.51˜7.69 (m, 3H), 3.80 (s, 2H); ES-MS m/z: 206.2 (M++1).

Provenance & Evidence