Hydrazine → HCID 59320315, compound

Participants

Reaction Conditions

Reaction Steps

To a 40 ml vial was added methanol (12 mL), [5,7-difluoro-3-(1-methyl-1H-pyrazol-4-yl)-quinolin-6-yl]-acetic acid methyl ester (508 mg, 1.6 mmol) and hydrazine anhydrous (4 eq., 6.4 mmols). After 1 hour at 55° C. a second portion of hydrazine (4 eq., 6.4 mmol) was added and the reaction heated at 55° C. for a further 1 hour. The reaction mixture was cool down to room temperature, filtered and washed with cold methanol. The product was dried to return the title compound as a white solid (425 mg, 83% yield). MS: m/z 318.0 (M+H+).

Provenance & Evidence